LTA4H Genotype Is Associated with Susceptibility to Bacterial Meningitis but Is Not a Critical Determinant of Outcome
نویسندگان
چکیده
Adjunctive dexamethasone saves lives in the treatment of tuberculous meningitis but this response is influenced by the patient's LTA4H genotype. Despite less certain benefit, adjunctive dexamethasone is also frequently used in the treatment of pyogenic bacterial meningitis, but the influence of LTA4H genotype on outcomes has not been previously investigated. We genotyped the LTA4H promoter region SNP (rs17525495) in 390 bacterial meningitis patients and 751 population controls. rs17525495 was associated with susceptibility to bacteriologically confirmed bacterial meningitis (P = 0.01, OR 1.27 95% confidence interval [CI] 1.05-1.54) but did not influence clinical presentation, disease severity or survival following dexamethasone treatment.
منابع مشابه
Gene polymorphism of leukotriene A4 hydrolase (rs17525495) among tuberculous meningitis and its associations with clinical corticosteroid treatments in Han population of Northern China
This study is to investigate the association between Leukotriene A4 hydrolase (LTA4H) single nucleotide polymorphisms and susceptibility to tuberculous meningitis (TBM) in Chinese Han population of Northern China, and its association with clinical treatment. Patients with TBM and healthy controls were enrolled. We investigated the gene polymorphism (rs17525495) of LTA4H and tuberculous meningit...
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متن کاملAdjunctive dexamethasone for the treatment of HIV-uninfected adults with tuberculous meningitis stratified by Leukotriene A4 hydrolase genotype (LAST
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